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In Germs, Genes and Civilization, Dr. David Clark tells the story of the microbe-driven epidemics that have repeatedly molded our human destinies. You'll discover how your genes have been shaped through millennia spent battling against infectious diseases. You'll learn how epidemics have transformed human history, over and over again, from ancient Egypt to Mexico, the Romans to Attila the Hun. You'll learn how the Black Death epidemic ended the Middle Ages, making possible the Renaissance, western democracy, and the scientific revolution. Clark demonstrates how epidemics have repeatedly shaped not just our health and genetics, but also our history, culture, and politics. You'll even learn how they may influence religion and ethics, including the ways they may help trigger cultural cycles of puritanism and promiscuity. Perhaps most fascinating of all, Clark reveals the latest scientific and philosophical insights into the interplay between microbes, humans, and society - and previews what just might come next.
Preface xiii
Chapter 1: Introduction: our debt to disease 1
Epidemics select genetic alterations 4
Every cloud has a silver lining: our debt to disease 6
Crowding and culling 8
The message of this book 11
Chapter 2: Where did our diseases come from? 13
Africa: homeland of mankind and malaria 13
Many human diseases originated in animals 17
Are new diseases virulent to start with? 24
Diseases from rodents 29
Leprosy is a relatively new disease 30
What goes around comes around 32
Chapter 3: Transmission, overcrowding, and virulence 33
Virulence and the spread of disease 33
Infectious and noninfectious disease 34
Many diseases become milder with time 40
Development of genetic resistance to disease 47
Hunting and gathering 56
How do microorganisms become dangerous? 60
Chapter 4: Water, sewers, and empires 67
Introduction: the importance of biology 67
Irrigation helps agriculture but spreads germs 68
The class system, water, and infection 69
The origin of diarrheal diseases 70
Cholera comes from the Indian subcontinent 71
Cholera and the water supply 72
The rise and fall of the Indus Valley civilization 74
Cities are vulnerable to waterborne diseases 76
Cholera, typhoid, and cystic fibrosis 78
How did disease affect the rise of Rome? 81
How much did malaria contribute to the fall of Rome? 83
Uncivilized humans and unidentified diseases 86
Bubonic plague makes an appearance 90
Chapter 5: Meat and vegetables 93
Eating is hazardous to your health 93