Bioprocess Engineering, Third Edition, is an extensive update of the world’s leading introductory textbook on biochemical and bioprocess engineering and reflects key advances in productivity, innovation, and safety.

The authors review relevant fundamentals of biochemistry, microbiology, and molecular biology, including enzymes, cell functions and growth, major metabolic pathways, alteration of cellular information, and other key topics. They then introduce evolving biological tools for manipulating cell biology more effectively and to reduce costs of bioprocesses.

This edition presents major advances in the production of biologicals; highly productive techniques for making heterologous proteins; new commercial applications for both animal and plant cell cultures; key improvements in recombinant DNA microbe engineering; techniques for more consistent authentic post-translational processing of proteins; and other advanced topics. It includes new, improved, or expanded coverage of

The role of small RNAs as regulators
Transcription, translation, regulation, and differences between prokaryotes and eukaryotes
Cell-free processes, metabolic engineering, and protein engineering
Biofuels and energy, including coordinated enzyme systems, mixed-inhibition and enzyme-activation kinetics, and two-phase enzymatic reactions
Synthetic biology
The growing role of genomics and epigenomics Population balances and the Gompetz equation for batch growth and product formation
Microreactors for scale-up/scale-down, including rapid scale-up of vaccine production
The development of single-use technology in bioprocesses
Stem cell technology and utilization
Use of microfabrication, nanobiotechnology, and 3D printing techniques
Advances in animal and plant cell biotechnology

The text makes extensive use of illustrations, examples, and problems, and contains references for further reading as well as a detailed appendix describing traditional bioprocesses.

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Sample Content

Online Sample Chapter

Enzymes

Part I: The Basics of Biology: An Engineer’s Perspective
Chapter 1: What Is a Bioprocess Engineer?
Chapter 2: An Overview of Biological Basics
Chapter 3: Enzymes
Chapter 4: How Cells Work
Chapter 5: Major Metabolic Pathways
Chapter 6: How Cells Grow
Chapter 7: Stoichiometry of Microbial Growth and Product Formation
Chapter 8: How Cellular Information Is Altered
Part II: Engineering Principles for Bioprocesses
Chapter 9: Operating Considerations for Bioreactors for Suspension and Immobilized Cultures
Chapter 10: Selection, Scale-Up, Operation, and Control of Bioreactors
Chapter 11: Recovery and Purification of Products
Chapter 12: Bioprocess Considerations in Using Animal Cell Cultures
Chapter 13: Bioprocess Considerations in Using Plant Cell Cultures
Chapter 14: Utilizing Genetically Engineered Organisms
Chapter 15: Medical Applications of Bioprocess Engineering
Chapter 16: Multiple Species in Culture
Appendix A: Traditional Industrial Bioprocesses

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Updates

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We've made every effort to ensure the accuracy of this book and its companion content. Any errors that have been confirmed since this book was published can be downloaded below.

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Bioprocess Engineering: Basic Concepts, 3rd Edition

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